Han Weinong, Li Hong, Xie Lu, Xu Liangguo, Zhang Ling, Yao Kaitai
Laboratory of Cancerous Change and Invasion, Xiangya Medical College, Central South University, Changsha 410078, China.
Zhonghua Zhong Liu Za Zhi. 2002 Mar;24(2):114-7.
To compare gene expression gene profile of nasopharyngeal carcinoma (NPC) tissue with that of normal nasopharyngeal tissues by cDNA array and to discuss possible functions of DNA repair-related genes in NPC tissue.
After hybridization of atlas human cancer cDNA expression array 7742 - 1, atlas hybridization results were analyzed by Atlas Image 1.01 a software package. Using RT-PCR was used to confirm the results.
Of 63 differentially expressed genes in quadrangle C including DNA damage response, repair & recombination-related genes, 6 DNA repair-related genes were up-regulated, 12 were down-regulated.
DNA repair-related genes may be involved in patho-physiological process of nasopharyngeal carcinoma.
采用cDNA芯片比较鼻咽癌组织与正常鼻咽组织的基因表达谱，探讨DNA修复相关基因在鼻咽癌组织中的可能作用。
将人类癌症cDNA表达图谱7742 - 1杂交后，用Atlas Image 1.01 a软件包分析杂交结果，并用RT-PCR验证结果。
在四边形C中63个差异表达基因中，包括DNA损伤反应、修复与重组相关基因，6个DNA修复相关基因上调，12个下调。
DNA修复相关基因可能参与鼻咽癌的病理生理过程。
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