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点燃大鼠的原发性和“转移性”癫痫发作发展

Primary and "transfer" seizure development in the kindled rat.

作者信息

Burnham W M

出版信息

Can J Neurol Sci. 1975 Nov;2(4):417-28. doi: 10.1017/s0317167100020564.

DOI:10.1017/s0317167100020564
PMID:1201529
Abstract

An investigation was made of both primary and "transfer" kindling as they occur in ipsilateral limbic sites. Primary kindling was found to involve progressive growth of afterdischarge (AD), propagation and convulsive behavior. It was noted that AD growth did not take place gradually but occurred in sudden, large increments. "Transfer" (a significant acceleration of secondary kindling) was found at every secondary limbic site. It was associated with the early appearance of full-blown AD's, super-normal propagation, and well-developed seizures. The post-transfer interference of primary site function previously reported by Goddard et al was also found, but it occurred in significant amounts only after transfer kindling of the amygdala. It is believed that the data offer some support for both of the hypothetical mechanisms of transfer which have been proposed.

摘要

对原发性和“转移”点燃现象进行了研究,这些现象发生在同侧边缘系统部位。发现原发性点燃涉及后放电(AD)的渐进性增长、传播和惊厥行为。值得注意的是,AD的增长并非逐渐发生,而是以突然的大幅增量出现。在每个次级边缘系统部位都发现了“转移”(继发性点燃的显著加速)。它与全面发作的AD的早期出现、超常传播和充分发展的癫痫发作有关。还发现了戈达德等人先前报道的原发性部位功能的转移后干扰,但仅在杏仁核转移点燃后才大量出现。据信,这些数据为已提出的两种转移假说机制都提供了一些支持。

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