Tanaka T, Lange H, Naquet R
Can J Neurol Sci. 1975 Nov;2(4):447-55. doi: 10.1017/s031716710002059x.
A longitudinal study of the effects of sleep on amygdaloid kindling showed that kindling disrupted normal sleep patterns by reducing REM sleep and increasing awake time. Few interictal spike discharges were observed during the awake stage, while a marked increase in discharge was observed during the light and deep sleep stages. No discharges were observed during REM sleep. During the immediate post-stimulation period the nonstimulated amygdala showed a much higher rate of spike discharge. On the other hand, there was an increase in spike discharge in the stimulated amygdala during natural sleep without preceding amygdaloid stimulation. Amygdaloid stimulation at the generalized seizure threshold during each sleep stage resulted in a generalized convulsion. The influence of subcortical electrical stimulation on kindled amygdaloid convulsions was investigated in a second experiment. Stimulation of the centre median and the caudate nucleus was without effect on kindled convulsions, while stimulation of the mesencephalic reticular formation at high frequency (300 Hz) reduced the latency of onset of kindled generalized convulsions. Stimulation of the nucleus ventralis lateralis of the thalamus at low frequency (10 Hz) prolonged the convulsion latency, and at high current levels blocked the induced convulsion. Stimulation in the central gray matter at low frequency (10 Hz) also blocked kindled amygdaloid convulsions.
一项关于睡眠对杏仁核点燃效应的纵向研究表明，点燃通过减少快速眼动睡眠和增加清醒时间扰乱了正常睡眠模式。在清醒阶段观察到很少的发作间期棘波放电，而在浅睡眠和深睡眠阶段观察到放电显著增加。在快速眼动睡眠期间未观察到放电。在刺激后即刻，未受刺激的杏仁核显示出更高的棘波放电率。另一方面，在没有先前杏仁核刺激的自然睡眠期间，受刺激的杏仁核中棘波放电增加。在每个睡眠阶段，在全身性发作阈值进行杏仁核刺激会导致全身性惊厥。在第二个实验中研究了皮层下电刺激对点燃的杏仁核惊厥的影响。刺激中央中核和尾状核对点燃惊厥没有影响，而高频（300赫兹）刺激中脑网状结构会缩短点燃全身性惊厥的发作潜伏期。低频（10赫兹）刺激丘脑腹外侧核会延长惊厥潜伏期，在高电流水平时会阻断诱发的惊厥。低频（10赫兹）刺激中央灰质也会阻断点燃的杏仁核惊厥。
