Lange H, Tanaka T, Naquet R
Electroencephalogr Clin Neurophysiol. 1977 Apr;42(4):564-74. doi: 10.1016/0013-4694(77)90220-6.
Recording electrodes were implanted stereotaxically in limbic and thalamic structures and the mesencephalic reticular formation in twelve cats. The animals were submitted to daily stimulation of the left amygdaloid nucleus following the technique for the kindling procedure, always combined with 5 h 30 min post-stimulation monitoring. After about 18 days, generalized convulsive activity was established. The following results concerning the quantitative evolution of spontaneously occurring interictal spikes were obtained. Amygdaloid nuclei, the hippocampus and the thalamic nucleus ventralis lateralis (VL) demonstrated an increase of discharge activity during the kindling procedure, following by a significant decrease after convulsions had been elicited. Thalamic nucleus centrum medianum (CM) was the only recording site investigated where the amount of interictal discharge increased and remained at a high level even after generalized convulsions had been established. Fourier analysis of slow oscillations in discharge generation yielded two main types of significant periodicity. A 165 min oscillation could be detected in all structures tested except reticular formation, which developed a 110 min cycle shared only with the thalamic CM. Significant correlations in spike activity were obtained from various structures. Stimulated amygdala seemed to have alternating relations with thalamic CM and VL, whereas stimultaneous oscillations excisted between MRF and CM. The occurrence of high voltage spikes in both contralateral and ipsilateral amygdalae was shown to be significantly correlated.
在12只猫中，通过立体定向技术将记录电极植入边缘系统、丘脑结构和中脑网状结构。按照点燃程序的技术，每天对动物的左侧杏仁核进行刺激，并始终在刺激后进行5小时30分钟的监测。大约18天后，出现了全身性惊厥活动。获得了以下关于自发发作间期棘波定量演变的结果。杏仁核、海马和丘脑腹外侧核（VL）在点燃过程中放电活动增加，在引发惊厥后显著减少。丘脑中央中核（CM）是唯一被研究的记录部位，其发作间期放电量增加，即使在全身性惊厥确立后仍保持在高水平。对放电产生的慢振荡进行傅里叶分析，得出两种主要的显著周期性类型。除网状结构外，在所有测试结构中都能检测到165分钟的振荡，网状结构形成了仅与丘脑CM共享的110分钟周期。从各种结构中获得了棘波活动的显著相关性。受刺激的杏仁核似乎与丘脑CM和VL有交替关系，而中脑网状结构（MRF）和CM之间存在同步振荡。结果表明，对侧和同侧杏仁核中高压棘波的出现具有显著相关性。
