Boot Cécile R L, Groothuis Jan T, Van Langen Herman, Hopman Maria T E
Department of Physiology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands.
J Appl Physiol (1985). 2002 Jun;92(6):2335-40. doi: 10.1152/japplphysiol.00340.2001.
The purpose of this study was to assess the relationship between inactivity and shear stress, the frictional force of blood against the endothelium, in spinal cord injury (SCI) subjects. SCI group offers a unique "model of nature" to study the effects of inactivity. Nine SCI subjects with upper (SCI-U) and 5 with a lower (SCI-L) motoneuron lesion and 10 able-bodied controls (C) were included. A venous blood sample was withdrawn to determine blood viscosity. Red blood cell velocities and arterial diameters of the common carotid artery (CCA) and common femoral artery (CFA) were measured by using echo-Doppler ultrasound in a supine position. No differences were observed in wall shear stress in the CCA between groups. In the CFA, peak and mean wall shear stress were significantly increased in SCI (14.1 and 1.2 Pa, respectively) compared with C (10.2 and 0.9 Pa, respectively). Because SCI-U and SCI-L showed no differences in shear stress levels, inactivity and not nerve degeneration seems to cause the elevated shear stress levels in the CFA in SCI. However, the lack of central neural control as a causal factor cannot be ruled out.
本研究的目的是评估脊髓损伤（SCI）患者中不活动与剪切应力（血液与内皮之间的摩擦力）之间的关系。SCI组为研究不活动的影响提供了一个独特的“自然模型”。纳入了9名患有上运动神经元损伤（SCI-U）的SCI患者、5名患有下运动神经元损伤（SCI-L）的患者以及10名健全对照者（C）。采集静脉血样以测定血液粘度。使用超声多普勒在仰卧位测量颈总动脉（CCA）和股总动脉（CFA）的红细胞速度和动脉直径。各组之间CCA的壁剪切应力未观察到差异。在CFA中，SCI患者的峰值和平均壁剪切应力（分别为14.1 Pa和1.2 Pa）显著高于C组（分别为10.2 Pa和0.9 Pa）。由于SCI-U和SCI-L在剪切应力水平上没有差异，因此不活动而非神经退变似乎导致了SCI患者CFA中剪切应力水平升高。然而，作为因果因素的中枢神经控制缺失也不能排除。
