Holmes Alexandra L, Burgess Helen J, Dawson Drew
Centre for Sleep Research, University of South Australia, Woodville, South Australia 5011, Australia.
J Appl Physiol (1985). 2002 Jun;92(6):2578-84. doi: 10.1152/japplphysiol.01106.2001.
This study investigated the effects of variations in sleep pressure on cardiac autonomic activity and body temperature. In a counterbalanced design, 12 healthy, young subjects (6 men and 6 women) remained recumbent during 30 h of wakefulness (high sleep pressure) and 6 h of wakefulness (low sleep pressure). Both periods of wakefulness were immediately followed by a sleep opportunity, and the first 2 h of sleep were analyzed. During extended hours of wakefulness, a reduction in heart rate was mediated by a decline in cardiac sympathetic activity (measured via preejection period) and the maintenance of cardiac parasympathetic activity (measured via respiratory sinus arrhythmia). In subsequent high-pressure sleep, parasympathetic activity was amplified and sympathetic activity was negatively associated with electroencephalographic slow-wave activity. Sleep deprivation had no impact on foot temperature, but it did alter the pattern of change in core body temperature. A downregulation of cardiac autonomic activity during both extended hours of wakefulness and subsequent sleep may respectively provide "protection" and "recovery" from the temporal extension of cardiac demand.
本研究调查了睡眠压力变化对心脏自主神经活动和体温的影响。在一项平衡设计中，12名健康的年轻受试者（6名男性和6名女性）在30小时清醒（高睡眠压力）和6小时清醒（低睡眠压力）期间保持卧位。两个清醒时段之后都紧接着有睡眠机会，并对睡眠的前2小时进行分析。在延长的清醒时间里，心率降低是由心脏交感神经活动下降（通过射血前期测量）和心脏副交感神经活动维持（通过呼吸性窦性心律不齐测量）介导的。在随后的高压睡眠中，副交感神经活动增强，交感神经活动与脑电图慢波活动呈负相关。睡眠剥夺对足部温度没有影响，但确实改变了核心体温的变化模式。在延长的清醒时间和随后的睡眠期间，心脏自主神经活动的下调可能分别为心脏需求的时间延长提供“保护”和“恢复”。
