Sajjadieh Amirreza, Shahsavari Ali, Safaei Ali, Penzel Thomas, Schoebel Christoph, Fietze Ingo, Mozafarian Nafiseh, Amra Babak, Kelishadi Roya
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Medical Student, Isfahan University of Medical Sciences, Isfahan, Iran.
Tanaffos. 2020 Nov;19(2):135-143.
The current study was conducted to evaluate the relation of sleep duration and quality with blood pressure (BP) and heart rate variability (HRV).
This cross-sectional study was carried out in 2017 among 260 staff of a university hospital in Isfahan, Iran. They were selected by multi-stage random method from different wards. Time domain spectral analysis was used to measure a number of HRV parameters. The long-term components of the HRV were estimated using the standard deviation of the normal-to-normal interval (SDNN). The square root of the mean squared differences of successive NN intervals (RMSSD) was calculated by statistical time domain measurements; SNN50, and PNN50 were measured. Pittsburg sleep quality index (PSQI) questionnaire was used to assess sleep quality.
Higher PSQI score correlated with lower SDANN rise (OR=0.92). Fairly bad to very good subjective sleep quality had association with lower SDANN (OR=0.43). Very high sleep latency to very low sleep latency ratio had association with lower SDANN (OR=0.39) and lower PNN50 (OR= 0.44). Sleep duration and HRV parameters had no significant association. Fairly bad sleep efficiency to very good sleep efficiency ratio was correlated with lower SDANN (OR= 0.29). Very high daytime dysfunction to very low daytime dysfunction ratio had correlation with lower SDANN (OR=0.35). Very bad compared to very good subjective sleep quality had significant correlation with higher Heart rate (HR) (B=0.03). Very high sleep latency compared to no sleep latency was associated with higher HR (B=4.74). Very high compared to very low amount of sleep disturbances correlated with higher SBP levels (B=15.2). Using sleep medication less than once a week compared with no history of taking such drugs was associated with higher HR (B=16.4).
Our findings showed that poor sleep quality are adversely associated with HRV, HR and BP. This finding should be considered in clinical and preventive recommendations.
本研究旨在评估睡眠时间和质量与血压（BP）及心率变异性（HRV）之间的关系。
本横断面研究于2017年在伊朗伊斯法罕一家大学医院的260名工作人员中进行。他们通过多阶段随机方法从不同病房选取。采用时域频谱分析来测量多个HRV参数。HRV的长期成分通过正常到正常间期的标准差（SDNN）进行估计。连续NN间期的均方根差（RMSSD）通过统计时域测量计算得出；测量了SNN50和PNN50。使用匹兹堡睡眠质量指数（PSQI）问卷来评估睡眠质量。
较高的PSQI评分与较低的SDANN升高相关（OR = 0.92）。相当差到非常好的主观睡眠质量与较低的SDANN相关（OR = 0.43）。非常高的睡眠潜伏期与非常低的睡眠潜伏期之比与较低的SDANN（OR = 0.39）和较低的PNN50（OR = 0.44）相关。睡眠时间与HRV参数无显著关联。相当差的睡眠效率与非常好的睡眠效率之比与较低的SDANN相关（OR = 0.29）。非常高的日间功能障碍与非常低的日间功能障碍之比与较低的SDANN相关（OR = 0.35）。与非常好的主观睡眠质量相比，非常差的主观睡眠质量与较高的心率（HR）显著相关（B = 0.03）。与无睡眠潜伏期相比，非常高的睡眠潜伏期与较高的HR相关（B = 4.74）。与非常低的睡眠干扰量相比，非常高的睡眠干扰量与较高的收缩压水平相关（B = 15.2）。与无服用此类药物史相比，每周使用睡眠药物少于一次与较高的HR相关（B = 16.4）。
我们的研究结果表明，睡眠质量差与HRV、HR和BP存在不良关联。这一发现应在临床和预防建议中予以考虑。
