空肠弯曲菌感染与吉兰-巴雷综合征的发展关系。
The relationship of Campylobacter jejuni infection and the development of Guillain-Barré syndrome.
作者信息
Tsang Raymond S W
机构信息
Central Nervous System Infection and Vaccine Preventable Bacterial Diseases Division, National Microbiology Laboratory, Population and Public Health Branch, Health Canada, Winnipeg, Manitoba, Canada.
出版信息
Curr Opin Infect Dis. 2002 Jun;15(3):221-8. doi: 10.1097/00001432-200206000-00002.
Campylobacter jejuni is recognized as the most common infectious agent associated with the development of Guillain-Barré syndrome. Available information on the complete genome sequence of C. jejuni NCTC 11168 has helped researchers to identify polysaccharide capsules as well as genetic mechanisms in the synthesis of ganglioside-like cell surface molecules in this bacteria. Toxins may contribute to the host's inflammatory response seen in Guillain-Barré syndrome.
空肠弯曲菌被认为是与吉兰-巴雷综合征发生相关的最常见感染因子。有关空肠弯曲菌NCTC 11168全基因组序列的现有信息，帮助研究人员识别出该细菌中的多糖荚膜以及合成神经节苷脂样细胞表面分子的遗传机制。毒素可能导致吉兰-巴雷综合征中所见的宿主炎症反应。
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