Mannan A, Wiebe L I, Noujaim A A, Secord D C
Clin Biochem. 1975 Oct;8(5):303-6. doi: 10.1016/s0009-9120(75)93350-0.
Plasma free amino acids in the sub-totally nephrectomized chronic uremic rat have been quantitated. The concentrations of these substances in uremic rats have been compared to levels present in sham-operated controls, and to levels found in normal rats on a restricted diet. Phosphoserine, alpha-aminoadipic acid, 1-methylhistidine and 3-methylhistidine concentrations were found to be significantly higher in the uremic group. Sub-normal amounts of serine, valine, tryptophan, asparagine and anserine were present in the serum of the uremic animals. No changes were detected in serum amino acids which are ketogenic. Serum glutamic oxaloacetic transaminase activity was reduced in both uremic and restricted diet rats.
已对次全肾切除的慢性尿毒症大鼠的血浆游离氨基酸进行了定量分析。将这些物质在尿毒症大鼠中的浓度与假手术对照组中的水平以及限食正常大鼠中发现的水平进行了比较。发现尿毒症组中磷酸丝氨酸、α-氨基己二酸、1-甲基组氨酸和3-甲基组氨酸的浓度显著更高。尿毒症动物血清中丝氨酸、缬氨酸、色氨酸、天冬酰胺和鹅肌肽的含量低于正常水平。生酮血清氨基酸未检测到变化。尿毒症大鼠和限食大鼠的血清谷氨酸草酰乙酸转氨酶活性均降低。
