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7-取代-1-乙基（2-氟乙基）-6,8-二氟-1,4-二氢-4-氧代喹啉-3-羧酸的合成与抗菌活性

[Synthesis and antibacterial activity of 7-substituted-1-ethyl(2-fluoro-ethyl)-6,8-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid].

作者信息

Yan L, Xu B, Ma Z, Zhu Y, Yang Q

机构信息

Shenyang Military District, Institute of Military Medicine, Shenyang 110031.

出版信息

Yao Xue Xue Bao. 1998 May;33(5):392-5.

PMID:12017009
Abstract

Eighteen 7-substituted-1-ethyl (2-fluoroethyl)-6, 8-difluoro-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid were designed and synthesized. The results of preliminary antibacterial test showed that most of the compounds exhibited definite activities in test against pathogenic bacteria. Especially, compound 17 and 18 showed better activities and surpassed fleroxacin when compared in vitro.

摘要

设计并合成了18个7-取代-1-乙基（2-氟乙基）-6,8-二氟-1,4-二氢-4-氧代喹诺酮-3-羧酸。初步抗菌试验结果表明，大多数化合物对病原菌有一定的活性。特别是化合物17和18表现出较好的活性，体外比较时超过了氟罗沙星。

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