Kumara Rohana, Zacharias Mathew
Department of Stomatology, School of Dentistry, PO Box 647, Dunedin.
N Z Dent J. 2002 Mar;98(431):9-11.
In a randomised, double-blind, cross-over trial, 15 healthy, young patients undergoing surgical removal of bilateral, impacted, third-molar teeth received the analgesic tramadol 50 mg, as a single dose, either 2 hours prior or immediately before the surgical procedure. There were no differences in the post-operative pain levels or degree of trismus between the two methods of administration of tramadol (P > 0.05), suggesting absence of any pre-emptive analgesic effect for the drug in the dose studied. The prevalence of unwanted side effects such as nausea (37 percent) was high within the first 24 hours.
在一项随机、双盲、交叉试验中，15名接受双侧阻生第三磨牙拔除手术的健康年轻患者，在手术前2小时或即将手术前接受了50毫克镇痛曲马多单剂量治疗。两种曲马多给药方法在术后疼痛水平或牙关紧闭程度上没有差异（P>0.05），这表明在所研究剂量下该药物不存在任何超前镇痛作用。在最初24小时内，恶心等不良副作用的发生率较高（37%）。
