Mitchell Christina A, Gurung Rajendra, Kong Anne M, Dyson Jennifer M, Tan April, Ooms Lisa M
Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.
IUBMB Life. 2002 Jan;53(1):25-36. doi: 10.1080/15216540210815.
Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.
最近的研究已确定肌醇多磷酸5-磷酸酶是一个信号修饰酶大家族，包含10个哺乳动物成员和4个酵母家族成员。包括对小鼠5-磷酸酶进行基因靶向缺失在内的多项研究表明，这些酶调节许多重要的细胞活动，包括造血细胞增殖与活化、胰岛素信号传导、胞吞作用以及肌动蛋白聚合。
