Farber Donna L, Ahmadzadeh Mojgan
Department of Surgery, Division of Transplantation, University of Maryland Medical School, Baltimore 21201, USA.
Immunol Res. 2002;25(3):247-59. doi: 10.1385/IR:25:3:247.
Memory immune responses are classically attributed to the reactivation of long-lived, antigen-specific T lymphocytes that persist in a quiescent state. Determining mechanisms for the generation of memory T cells and dissecting the functional nature of the memory T cell pool has been encumbered by an inability to distinguish recently activated effector T cells from memory T cells. We have established new activation and biochemical criteria that distinguish effector and memory T cells and have applied these criteria to follow memory generation from activated cells in vivo. We found that the resultant memory T cell pool is heterogeneous and consists of effector-like and resting memory-like subsets that differ in expression of the homing receptor, CD62L. We discuss these findings in the context of memory T cell heterogeneity identified in human and mouse systems. These results suggest that more than one type of previously activated T cell can mediate recall or memory immune responses and that elucidating the fundamental phenotypic and functional features of memory T cell subsets is therefore critical to deciphering the complex nature of the memory immune response.
记忆免疫反应传统上归因于长期存在的、抗原特异性的T淋巴细胞重新激活，这些T淋巴细胞处于静止状态。由于无法区分最近激活的效应T细胞和记忆T细胞，确定记忆T细胞产生的机制以及剖析记忆T细胞库的功能特性一直受到阻碍。我们已经建立了区分效应T细胞和记忆T细胞的新激活和生化标准，并应用这些标准追踪体内激活细胞产生记忆的过程。我们发现，产生的记忆T细胞库是异质性的，由归巢受体CD62L表达不同的效应样和静止记忆样亚群组成。我们在人类和小鼠系统中鉴定出的记忆T细胞异质性背景下讨论这些发现。这些结果表明，不止一种类型的先前激活的T细胞可以介导回忆或记忆免疫反应，因此阐明记忆T细胞亚群的基本表型和功能特征对于解读记忆免疫反应的复杂性质至关重要。
