Ahmadzadeh Mojgan, Farber Donna L
Department of Surgery, University of Maryland School of Medicine, MSTF Building, Room 400, 685 West Baltimore Street, Baltimore, MD 21201, USA.
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11802-7. doi: 10.1073/pnas.192263099. Epub 2002 Aug 21.
The protective nature of memory immune responses is attributed largely to terminally differentiated memory T cells that retain memory of the antigen via the antigen receptor and memory of the effector functions that initially cleared the pathogen. It is not known whether a given population of antigen-specific memory T cells is endowed with functional flexibility to provide protective responses against antigens reencountered in different immunological contexts. Here, we examine functional properties of influenza hemagglutinin (HA)-specific memory CD4 T cells recovered from adoptive hosts that received in vitro-activated HA-specific T cell receptor-transgenic CD4 T cells 2 months to 1 year previously. We demonstrate that this HA-specific memory CD4 T cell population bearing a clonal T cell receptor can produce predominantly T helper 1 or T helper 2 effector cytokines depending on the nature of the recall stimulus. Our findings reveal remarkable functional plasticity within an antigen-specific memory T cell population and have direct implications for modulating memory T cell function in vaccine design and treatments for autoimmune diseases.
记忆性免疫反应的保护性很大程度上归因于终末分化的记忆性T细胞，这些细胞通过抗原受体保留对抗原的记忆，并保留最初清除病原体的效应功能的记忆。尚不清楚特定群体的抗原特异性记忆性T细胞是否具有功能灵活性，以针对在不同免疫背景下再次遇到的抗原提供保护性反应。在此，我们研究了从过继宿主中回收的流感血凝素（HA）特异性记忆性CD4 T细胞的功能特性，这些宿主在2个月至1年前接受了体外激活的HA特异性T细胞受体转基因CD4 T细胞。我们证明，这群携带克隆性T细胞受体的HA特异性记忆性CD4 T细胞可根据回忆刺激的性质主要产生辅助性T细胞1型或辅助性T细胞2型效应细胞因子。我们的研究结果揭示了抗原特异性记忆性T细胞群体中显著的功能可塑性，对疫苗设计和自身免疫性疾病治疗中调节记忆性T细胞功能具有直接意义。
