Geer B W, Lindel D L, Lindel D M
Biochem Genet. 1979 Oct;17(9-10):881-95. doi: 10.1007/BF00504310.
The tissue activities of the oxidative pentose shunt enzymes, glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49) and 6-phosphogluconate dehydrogenase (E.C. 1.1.1.44), in the larvae of Drosophila melanogaster are not dependent on the amount of flux through the oxidative pentose shunt pathway. An oxidative pentose shunt deficiency effects about a 40% reduction in the NADPH concentration in early third instar larvae, resulting in a six-fold difference in the NADPH/NADP+ ratio between wild-type and pentose-shunt-deficient larvae. The capacity of pentose-shunt-deficient larvae to synthesize triglyceride in response to a high concentration of dietary sucrose is only 73% of the wild-type level. Environmental temperature influences on the fatty acid composition of larvae are not altered by an oxidative pentose shunt deficiency.
在黑腹果蝇幼虫中，氧化戊糖支路酶（葡萄糖-6-磷酸脱氢酶，E.C. 1.1.1.49；6-磷酸葡萄糖酸脱氢酶，E.C. 1.1.1.44）的组织活性并不依赖于通过氧化戊糖支路途径的通量。氧化戊糖支路缺陷导致三龄早期幼虫中NADPH浓度降低约40%，使得野生型幼虫和戊糖支路缺陷型幼虫之间的NADPH/NADP+比值相差6倍。戊糖支路缺陷型幼虫在高浓度膳食蔗糖作用下合成甘油三酯的能力仅为野生型水平的73%。氧化戊糖支路缺陷不会改变环境温度对幼虫脂肪酸组成的影响。
