Riising H J, van Empel P, Witvliet M
Intervet Danmark, Skovlunde, Denmark.
Vet Rec. 2002 May 4;150(18):569-71. doi: 10.1136/vr.150.18.569.
The efficacy of a new vaccine against atrophic rhinitis in pigs was tested in the Netherlands and Denmark. The vaccine contained protein dO (a truncated Pasteurella multocida toxin which is immunogenic and non-toxic), inactivated Bordetella bronchiseptica whole cells, and an adjuvant. The sows were either vaccinated intramuscularly with 2 ml of the vaccine at six to eight and two to four weeks before expected farrowing or left unvaccinated as controls. All the piglets were challenged intranasally with B bronchiseptica when three to seven days old and with P multocida three to four days later. Pigs born to the vaccinated sows performed significantly better than pigs born to the control sows when judged on growth, average daily weight gain and snout scores. The challenge organisms were reisolated more frequently from the control pigs than from the pigs in the vaccinated group. The vaccinated sows and their progeny developed high titres of antibodies against B bronchiseptica and P multocida toxin.
一种针对猪萎缩性鼻炎的新型疫苗在荷兰和丹麦进行了功效测试。该疫苗含有蛋白dO（一种截短的多杀性巴氏杆菌毒素，具有免疫原性且无毒）、灭活的支气管败血波氏杆菌全细胞以及一种佐剂。母猪在预计分娩前6至8周和2至4周时，要么肌肉注射2毫升该疫苗，要么不接种作为对照。所有仔猪在3至7日龄时经鼻接种支气管败血波氏杆菌，3至4天后接种多杀性巴氏杆菌。从生长、平均日增重和鼻部评分来判断，接种疫苗的母猪所生仔猪的表现明显优于对照母猪所生仔猪。与接种疫苗组的猪相比，对照猪中更频繁地重新分离出攻击生物体。接种疫苗的母猪及其后代产生了高滴度的针对支气管败血波氏杆菌和多杀性巴氏杆菌毒素的抗体。
