纳诺霉素，由链霉菌菌株产生的新型抗生素。II. 结构与生物合成。
Nanomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis.
作者信息
Tanaka H, Koyama Y, Nagai T, Marumo H, Omura S
出版信息
J Antibiot (Tokyo). 1975 Nov;28(11):868-75. doi: 10.7164/antibiotics.28.868.
PMID:1201970
Abstract
Evidence is put forward which describes the structure and stereochemistry of new antibiotics, nanaomycins A and B, as I and V, respectively. In order to study biosynthesis and to determine the position of the hydroxyl group in the naphthoquinone moiety, a feeding experiment with 1-13C-acetate was effectively carried out. Nanaomycins A and B were found to be synthesized from acetate via a polyketide by Streptomyces rosa var. notoensis.
摘要
有证据表明，新型抗生素那纳霉素A和B的结构和立体化学分别如I和V所示。为了研究生物合成并确定萘醌部分中羟基的位置，有效地进行了用1-13C-乙酸盐的饲喂实验。发现那纳霉素A和B是由玫瑰链霉菌变种诺托链霉菌通过聚酮化合物由乙酸盐合成的。
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