Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives.

A new component, nanaomycin C, has been isolated from culture medium of Streptomyces rosa var. notoensis, which had been found to produce nanaomycins A and B. Nanaomycin C is an amide of nanaomycin A. Biological activities of nanaomycin C and several derivatives of nanaomycin A are also shown. Acetylnanaomycin A exhibits as strong activities against Gram-positive bacteria, fungi and Mycoplasma gallisepticum as nanaomycin A.