纳那霉素，由一株链霉菌产生的新型抗生素。I. 分类学、分离、特性及生物学特性

Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties.

作者信息

Tanaka H, Koyama Y, Awaya J, Marumo H, Oiwa R

出版信息

J Antibiot (Tokyo). 1975 Nov;28(11):860-7. doi: 10.7164/antibiotics.28.860.

DOI:10.7164/antibiotics.28.860

PMID:1201969

Abstract

Nanomycins are new antibiotics produced by the strain OS-3966 which was designated Streptomyces rosa var. notoensis. Nanomycins A and B were isolated from the culture filtrate by extraction with organic solvent and silica gel chromatography. The physical and chemical properties suggest that nanaomycins A and B are quinone-related compounds having the molecular formulae, C16H14O6 and C16H16O7, respectively. Nanaomycins A and B inhibit mainly mycoplasmas, fungi and Gram-positive bacteria. The acute toxicities (LD50, ip) of nanaomycins A and B in mice are 28.2 and 169 mg/kg, respectively.

摘要

纳那霉素是由菌株OS - 3966产生的新型抗生素，该菌株被命名为玫瑰链霉菌诺托变种。通过有机溶剂萃取和硅胶柱色谱法从培养滤液中分离出纳那霉素A和B。其理化性质表明，纳那霉素A和B是醌类相关化合物，分子式分别为C16H14O6和C16H16O7。纳那霉素A和B主要抑制支原体、真菌和革兰氏阳性菌。纳那霉素A和B对小鼠的急性毒性（腹腔注射LD50）分别为28.2和169 mg/kg。