Sutherland M A, Mellor D J, Stafford K J, Gregory N G, Bruce R A, Ward R N
Animal Welfare Science and Bioethics Centre, College of Sciences, Massey University, Palmerston North, New Zealand.
Aust Vet J. 2002 Mar;80(3):165-7. doi: 10.1111/j.1751-0813.2002.tb11385.x.
To reassess whether local anaesthesia before dehorning and wound cauterisation after dehorning eliminates the cortisol response to dehorning.
A control group was compared with three dehorned groups (dehorned alone, dehorned after local anaesthesia, dehorned after local anaesthesia then cautery of the amputation wounds). The local anaesthetic regimen used produced nerve blockade for about 5 h. Blood samples were taken before and after dehorning and plasma cortisol concentrations were determined.
Dehorning caused a marked cortisol response lasting for about 7 h. Local anaesthetic reduced the plasma cortisol concentrations to control values for 5 h, after which they increased for a further 5 h. Subsequently in both groups, cortisol concentrations remained at control values until at least 24 h after treatment. Local anaesthetic combined with wound cautery virtually abolished the cortisol response until at least 24 h after dehorning.
Combining local anaesthesia with cautery of the amputation wounds substantially reduced the cortisol response until at least 24 h after dehorning.
重新评估去角前局部麻醉及去角后伤口烧灼是否能消除去角引起的皮质醇反应。
将一个对照组与三个去角组（单纯去角、局部麻醉后去角、局部麻醉后去角然后烧灼截肢伤口）进行比较。所采用的局部麻醉方案产生约5小时的神经阻滞。在去角前后采集血样并测定血浆皮质醇浓度。
去角引起明显的皮质醇反应，持续约7小时。局部麻醉使血浆皮质醇浓度在5小时内降至对照值，之后又升高5小时。随后在两组中，皮质醇浓度在治疗后至少24小时内一直保持在对照值。局部麻醉联合伤口烧灼几乎消除了皮质醇反应，直至去角后至少24小时。
局部麻醉与截肢伤口烧灼相结合可显著降低皮质醇反应，直至去角后至少24小时。
