Milligan Barry N, Duffield Todd, Lissemore Kerry
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Can Vet J. 2004 Feb;45(2):140-3.
To determine if ketoprofen, in addition to local anaesthesia, reduces pain following dehorning, we experimentally dehorned dairy calves, less than 2 weeks of age, with (20 calves) or without (20 calves) intramuscular injections of ketoprofen. All calves received a local anesthetic (lidocaine) prior to dehorning and were dehorned with heat cauterization. Cortisol concentration was measured via jugular blood samples taken immediately before dehorning and at 3 and 6 hours following dehorning. Calf behavior was recorded between 0 and 2, 3 and 5, and 6 and 8 hours following dehorning. There was no significant (P > 0.10) effect on creep feed consumption, cortisol concentration, or any of the behavioral measures during the time periods studied. However, the difference in cortisol concentrations from the time of dehorning until 3 hours later was significantly lower (P < 0.05) in the ketoprofen-treated group. These results suggest that ketoprofen, in addition to local anesthesia, may alleviate short-term pain following dehorning with a butane dehorning device in dairy calves less than 2 weeks of age.
为了确定酮洛芬除局部麻醉外，是否能减轻去角后的疼痛，我们对2周龄以下的奶牛犊进行了实验性去角，其中20头犊牛在去角前进行了肌肉注射酮洛芬，另外20头犊牛未注射。所有犊牛在去角前均接受了局部麻醉（利多卡因），并采用热烧灼法去角。通过在去角前、去角后3小时和6小时采集的颈静脉血样测量皮质醇浓度。在去角后的0至2小时、3至5小时和6至8小时记录犊牛的行为。在所研究的时间段内，对犊牛的自由采食量、皮质醇浓度或任何行为指标均无显著影响（P>0.10）。然而，酮洛芬治疗组从去角时到3小时后的皮质醇浓度差异显著较低（P<0.05）。这些结果表明，对于2周龄以下的奶牛犊，除局部麻醉外，酮洛芬可能会减轻使用丁烷去角器去角后的短期疼痛。
