β-半乳糖苷酶抑制剂吡啶吲哚洛尔的结构

Structure of pyridindolol, inhibitor of beta-galactosidase.

作者信息

Kumagai M, Naganawa H, Aoyagi T, Umezawa H

出版信息

J Antibiot (Tokyo). 1975 Nov;28(11):876-80. doi: 10.7164/antibiotics.28.876.

DOI:10.7164/antibiotics.28.876

PMID:1201971

Abstract

Pyridindolol is a product of a streptomyces and exhibits inhibitory activity against bovine liver beta-galactosidase. The structure of pyridindilol, 1-[1(R), 2-dihydroxyethyl]-3-hydroxymethyl-9H-pyrido[3,4-b] indole, has been established by spectroscopic analyses and an X-ray structure determination.

摘要

吡啶吲哚洛尔是一种链霉菌产物，对牛肝β-半乳糖苷酶具有抑制活性。吡啶吲哚洛尔的结构，即1-[1(R), 2-二羟乙基]-3-羟甲基-9H-吡啶并[3,4-b]吲哚，已通过光谱分析和X射线结构测定得以确定。