Reisin Hernán D, Colombo Jorge A
Unidad de Neurobiología Aplicada (CEMIC-CONICET), Av. Galván 4102, 1431 Buenos Aires, Argentina.
Brain Res. 2002 May 24;937(1-2):51-7. doi: 10.1016/s0006-8993(02)02464-2.
Among mammalian species, astroglial interlaminar processes are unique features of the primate cerebral cortex. The morphological diversity in the immunocytochemical expression of their cytoskeleton was analyzed. For this purpose, samples from normal human cerebral cortex from autopsy cases were used. While Fractal dimension failed to represent the actual complexity of interlaminar processes, Compression analysis allowed classification of these profiles according to their relative tortuosity. Conversion of Compression values into estimates of membrane surface suggested that profile changes could not only affect the directionality of dynamic events, but also the amount of glial cell membrane exposed to the local neuropil. Terminal segments of interlaminar processes were usually more tightly twisted than the cytoskeleton stalk, and enlarged in aged individuals. If not aberrant structures, these so-called 'terminal masses' may provide an additional means to increase local membrane availability. Based on Compression analysis, categories of the geometric variability of the cytoskeleton of cerebral cortex interlaminar glial processes are presented.
在哺乳动物物种中，星形胶质细胞层间突起是灵长类动物大脑皮层的独特特征。分析了它们细胞骨架免疫细胞化学表达的形态多样性。为此，使用了来自尸检病例的正常人类大脑皮层样本。虽然分形维数未能代表层间突起的实际复杂性，但压缩分析允许根据它们的相对曲折度对这些轮廓进行分类。将压缩值转换为膜表面积估计值表明，轮廓变化不仅会影响动态事件的方向性，还会影响暴露于局部神经毡的神经胶质细胞膜的数量。层间突起的末端段通常比细胞骨架茎更紧密地扭曲，并且在老年个体中会增大。如果不是异常结构，这些所谓的“末端团块”可能提供增加局部膜可用性的额外手段。基于压缩分析，给出了大脑皮层层间神经胶质突起细胞骨架几何变异性的类别。
