Tanaka Shoichiro, Kobayashi Tetsuro, Nakanishi Koji, Okubo Minoru, Odawara Masato, Murase Toshio, Hashimoto Masaji, Watanabe Goro, Matsushita Hiroshi, Inoko Hidetoshi, Takeuchi Kazuo
Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo 105-8470, Japan.
Ann N Y Acad Sci. 2002 Apr;958:152-9.
Histopathological changes of biopsied pancreata were examined in three diabetic patients with autoimmune chronic pancreatitis (ACP). We found intra- and periinsular mononuclear cell (MNC)-mainly CD8+ T cell-infiltration as well as MNC infiltration around the ductal cells. Islet beta cell volume decreased significantly. Some ductal cells expressed insulin and insulin promoter factor-1 concomitantly in the affected pancreas. These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment-responsive diabetes associated with ACP.
对3例自身免疫性慢性胰腺炎（ACP）糖尿病患者活检胰腺的组织病理学变化进行了检查。我们发现胰岛内和周围有单核细胞（MNC）浸润，主要是CD8 + T细胞浸润，以及导管细胞周围的MNC浸润。胰岛β细胞体积显著减小。在受影响的胰腺中，一些导管细胞同时表达胰岛素和胰岛素启动因子-1。这些发现为理解与ACP相关的糖皮质激素治疗反应性糖尿病的病理机制提供了新的见解。
