Knutson B, Wolkowitz O M, Cole S W, Chan T, Moore E A, Johnson R C, Terpstra J, Turner R A, Reus V I
Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143-0984, USA.
Am J Psychiatry. 1998 Mar;155(3):373-9. doi: 10.1176/ajp.155.3.373.
The authors sought to test the causal hypothesis that serotonergic function modulates aspects of the normal spectrum of individual differences in affective experience and social behavior in humans.
A selective serotonin reuptake inhibitor (SSRI), paroxetine, 20 mg/day (N = 26), or placebo (N = 25) was administered to normal volunteers in a double-blind manner for 4 weeks, and personality variables and social behavior were assessed at baseline and at weeks 1 and 4 of treatment.
Relative to placebo, SSRI administration reduced focal indices of hostility through a more general decrease in negative affect, yet did not alter indices of positive affect. In addition, SSRI administration increased a behavioral index of social affiliation. Changes in both negative affect and affiliative behavior were significantly related to volunteers' plasma SSRI levels at the end of the experiment.
Central serotonergic function may modulate a dimension of normal personality characterized by reduced negative affective experience and increased affiliative behavior. SSRI administration has significant and detectable effects on these measures even in the absence of baseline clinical depression or other psychopathology.
作者试图验证一种因果假设，即血清素能功能调节人类情感体验和社会行为中个体差异正常范围的各个方面。
以双盲方式给正常志愿者服用20毫克/天的选择性5-羟色胺再摄取抑制剂（SSRI）帕罗西汀（N = 26）或安慰剂（N = 25），为期4周，并在基线以及治疗第1周和第4周评估人格变量和社会行为。
相对于安慰剂，服用SSRI通过更普遍地降低负面情绪减少了敌意的集中指标，但未改变正面情绪指标。此外，服用SSRI增加了社会归属感的行为指标。负面情绪和归属行为的变化与实验结束时志愿者的血浆SSRI水平显著相关。
中枢血清素能功能可能调节正常人格的一个维度，其特征是负面情感体验减少和归属行为增加。即使在没有基线临床抑郁症或其他精神病理学的情况下，服用SSRI对这些指标也有显著且可检测到的影响。
