Kannen Kyra, Aslan Behrem, Boetzel Cindy, Herrmann Christoph S, Lux Silke, Rosen Helena, Selaskowski Benjamin, Wiebe Annika, Philipsen Alexandra, Braun Niclas
Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Experimental Psychology Lab, Department of Psychology, Carl von Ossietzky University, Oldenburg, Germany.
Front Psychiatry. 2022 Jul 18;13:928145. doi: 10.3389/fpsyt.2022.928145. eCollection 2022.
A repeated finding regarding event-related potentials (ERPs) is that patients with ADHD show a reduced P300 amplitude. This raises the question of whether the attention of ADHD patients can be increased by stabilizing the P300. Assuming that the P300 is generated by event-related oscillations (EROs) in the low frequency range (0-8 Hz), one approach to increase the P300 could be to stimulate the patient's P300 underlying ERO by means of transcranial alternating current stimulation (tACS). The aim of this follow-up study was to investigate this hypothesized mechanism of action in adult ADHD patients.
Undergoing a crossover design, 20 adult ADHD patients (10 female) received an actual stimulation tACS on one day and a sham stimulation on another day. Before and after each intervention, EEG characteristics (P300 amplitudes, low frequency power) and attention performances (d2 attention test, visual oddball task (VOT)) were recorded.
Electrophysiological analyses revealed no evidence for an enhanced P300 amplitude or low frequency power increase after actual stimulation compared to sham stimulation. Instead, a significant effect was found for a stronger N700 amplitude increase after actual stimulation compared to sham stimulation. Consistent with the P300 null results, none of the examined neuropsychological performance measures indicated a tACS-induced improvement in attentional ability.
Contrary to a previous study using tACS to modulate the P300 in adult ADHD patients, the current study yields no evidence that tACS can increase the P300 amplitude in adult ADHD patients and that such P300 enhancement can directly improve neuropsychological parameters of attention.
关于事件相关电位（ERP）的一个反复出现的发现是，注意缺陷多动障碍（ADHD）患者的P300波幅降低。这就提出了一个问题，即能否通过稳定P300来提高ADHD患者的注意力。假设P300是由低频范围（0 - 8Hz）的事件相关振荡（ERO）产生的，一种提高P300的方法可能是通过经颅交流电刺激（tACS）来刺激患者P300潜在的ERO。这项随访研究的目的是调查这种假设的作用机制在成年ADHD患者中的情况。
采用交叉设计，20名成年ADHD患者（10名女性）在一天接受实际的tACS刺激，在另一天接受假刺激。每次干预前后，记录脑电图特征（P300波幅、低频功率）和注意力表现（d2注意力测试、视觉Oddball任务（VOT））。
电生理分析显示，与假刺激相比，实际刺激后没有证据表明P300波幅增强或低频功率增加。相反，与假刺激相比，实际刺激后发现N700波幅有更显著的增加。与P300的无效结果一致，所检查的神经心理学表现指标均未表明tACS能改善注意力。
与之前一项使用tACS调节成年ADHD患者P300的研究相反，本研究没有证据表明tACS能增加成年ADHD患者的P300波幅，且这种P300增强能直接改善注意力的神经心理学参数。
