Falkai Peter, Honer William G, Alfter Daniela, Schneider-Axmann Thomas, Bussfeld Patrick, Cordes Joachim, Blank Bettina, Schönell Helmut, Steinmetz Helmuth, Maier Wolfgang, Tepest Ralf
Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany.
Neurosci Lett. 2002 May 31;325(1):25-8. doi: 10.1016/s0304-3940(02)00224-0.
To investigate the effect of genetic loading on brain structure in schizophrenia, we hypothesized that separating families into uniaffected and multiply affected would reveal effects of schizophrenia and family type. Volumes and asymmetries of the amygdala-hippocampus-complex (AHC) and sylvian fissure (SF) were determined using magnetic resonance imaging of subjects with schizophrenia from 12 uniaffected and 14 multiply affected families, and ten healthy controls. AHC volume was reduced in schizophrenia, particularly on the right side in subjects from uniaffected families. AHC asymmetry was disturbed, too. Enlargement of the right SF and disturbed SF asymmetry was demonstrated in subjects from uniaffected families as well. Comparing subjects from uni- and multiply affected families may be a useful strategy to reduce variability for future studies of environmental interactions with genetic risk for schizophrenia.
为研究基因负荷对精神分裂症脑结构的影响，我们假设将家庭分为未患病和多个成员患病两类，会揭示精神分裂症及家庭类型的影响。我们使用磁共振成像技术，对来自12个未患病家庭和14个多个成员患病家庭的精神分裂症患者以及10名健康对照者的杏仁核 - 海马复合体（AHC）和外侧裂（SF）的体积及不对称性进行了测定。精神分裂症患者的AHC体积减小，尤其是来自未患病家庭的患者右侧AHC体积减小。AHC的不对称性也受到了干扰。来自未患病家庭的患者还表现出右侧SF增宽以及SF不对称性紊乱。比较来自单个成员患病和多个成员患病家庭的患者，可能是一种有用的策略，可减少未来关于精神分裂症遗传风险与环境相互作用研究中的变异性。
