Mayer Leonard W, Reeves Michael W, Al-Hamdan Nasser, Sacchi Claudio T, Taha Muhamed-Kheir, Ajello Gloria W, Schmink Susanna E, Noble Corie A, Tondella Maria Lucia C, Whitney Anne M, Al-Mazrou Yagoub, Al-Jefri Mohammed, Mishkhis Amin, Sabban Sameer, Caugant Dominique A, Lingappa Jairam, Rosenstein Nancy E, Popovic Tanja
Meningitis and Special Pathogens, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
J Infect Dis. 2002 Jun 1;185(11):1596-605. doi: 10.1086/340414. Epub 2002 May 17.
In 2000, >400 cases of disease caused by Neisseria meningitidis serogroup W135 (MenW135), the largest MenW135 outbreak reported to date, occurred worldwide among Hajj pilgrims and their contacts. To elucidate the origin of the outbreak strains and to investigate their relatedness to major clonal groups, genotypic and phenotypic subtyping was performed on 26 MenW135 outbreak-associated isolates and 50 MenW135 isolates collected worldwide from 1970 through 2000. All outbreak-associated isolates were members of a single clone of the hypervirulent electrophoretic type (ET)-37 complex, designated the "(W)ET-37 clone"; 19 additional MenW135 strains were also members of this clone, and the remaining 31 MenW135 strains were clearly distinct. The 2000 MenW135 outbreak was not caused by emergence of a new MenW135 strain but rather by expansion of the (W)ET-37 clone that has been in circulation at least since 1970; the strains most closely related to those causing the 2000 outbreak have been isolated in Algeria, Mali, and The Gambia in the 1990s.
2000年，脑膜炎奈瑟菌W135群（MenW135）引发的疾病出现了400多例，这是迄今为止报告的最大规模的MenW135疫情，在朝觐者及其接触者中全球范围内爆发。为了阐明疫情菌株的起源并调查它们与主要克隆群的相关性，对26株与MenW135疫情相关的分离株以及1970年至2000年期间在全球收集的50株MenW135分离株进行了基因型和表型分型。所有与疫情相关的分离株均为高毒力电泳型（ET）-37复合体单一克隆的成员，命名为“（W）ET-37克隆”；另外19株MenW135菌株也是该克隆的成员，其余31株MenW135菌株明显不同。2000年的MenW135疫情并非由新的MenW135菌株出现所致，而是由至少自1970年以来就已在传播的（W）ET-37克隆的扩张引起；与导致2000年疫情的菌株关系最密切的菌株已于20世纪90年代在阿尔及利亚、马里和冈比亚分离出来。
