Ransohoff R M
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
J Infect Dis. 2002 Dec 1;186 Suppl 2:S152-6. doi: 10.1086/344266.
Chemokines and their receptors govern physiologic and pathologic leukocyte trafficking. The function of the chemokine system may be of particular interest for hematogenous leukocyte infiltration of the central nervous system (CNS) because of the distinct character of CNS inflammation and the exquisite specificity with which the chemokine system regulates cellular migration events. This review summarizes recent information about the expression and function of elements of the chemokine system in CNS inflammatory processes. Animal models of CNS demyelinating disease and the corresponding human disorder, multiple sclerosis are both considered.
趋化因子及其受体调控着生理和病理性白细胞的迁移。由于中枢神经系统（CNS）炎症的独特性质以及趋化因子系统调节细胞迁移事件的高度特异性，趋化因子系统的功能可能对中枢神经系统血源性白细胞浸润尤为重要。本综述总结了关于趋化因子系统各成分在中枢神经系统炎症过程中的表达和功能的最新信息。文中同时考虑了中枢神经系统脱髓鞘疾病的动物模型以及相应的人类疾病——多发性硬化症。
