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奥维霉素，一种由产竹桃霉素的抗生素链霉菌ATCC11891基因编码的特殊安古霉素。

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891.

作者信息

Méndez Carmen, Künzel Eva, Lipata Fredilyn, Lombó Felipe, Cotham William, Walla Michael, Bearden Daniel W, Braña Alfredo F, Salas Jose A, Rohr Jürgen

机构信息

Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.

出版信息

J Nat Prod. 2002 May;65(5):779-82. doi: 10.1021/np010555n.

DOI:10.1021/np010555n
PMID:12027768
Abstract

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R(-)M(-) as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

摘要

我们利用II型聚酮合酶基因探针（actI/III）发现新型天然代谢产物的研究，在应用于产竹桃霉素（1）的抗生素链霉菌ATCC11891时，产生了一种不寻常的安古环素类化合物，卵形霉素（2）。该新型天然产物是以白色链霉菌R（-）M（-）作为宿主菌株生产的，将含有卵形霉素基因簇的黏粒转化到该宿主菌株中。通过核磁共振光谱和质谱对其结构进行了阐明。

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1
Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891.奥维霉素，一种由产竹桃霉素的抗生素链霉菌ATCC11891基因编码的特殊安古霉素。
J Nat Prod. 2002 May;65(5):779-82. doi: 10.1021/np010555n.
2
Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.抗生素链霉菌ATCC 11891中抗肿瘤安古霉素奥维霉素生物合成基因簇的遗传组织。
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A cytochrome P450-like gene possibly involved in oleandomycin biosynthesis by Streptomyces antibioticus.一个可能参与抗生链霉菌生产竹桃霉素的细胞色素P450样基因。
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Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.一种编码具有异常编码序列的I型聚酮合酶的抗生链霉菌基因的表征。
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Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily.抗生链霉菌含有至少三种竹桃霉素抗性决定簇，其中之一与ABC转运蛋白超家族的蛋白质具有相似性。
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Intracellular glycosylation and active efflux as mechanisms for resistance to oleandomycin in Streptomyces antibioticus, the producer organism.在抗生素链霉菌（产生该抗生素的生物体）中，细胞内糖基化和主动外排作为对竹桃霉素耐药的机制。
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Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.对参与竹桃霉素生物合成的天蓝色链霉菌染色体区域的分析，该区域编码负责大环内酯环糖基化的两种糖基转移酶。
Mol Gen Genet. 1998 Aug;259(3):299-308. doi: 10.1007/s004380050816.
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A second ABC transporter is involved in oleandomycin resistance and its secretion by Streptomyces antibioticus.第二种ABC转运蛋白参与了抗北里霉素以及北里链霉菌对其的分泌过程。
Mol Microbiol. 1995 Apr;16(2):333-43. doi: 10.1111/j.1365-2958.1995.tb02305.x.

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