Graf Werner, Gerrits Nicolaas, Yatim-Dhiba Najiya, Ugolini Gabriella
Laboratoire de Physiologie de la Perception et de l'Action, CNRS-Collège de France, Paris, France.
Eur J Neurosci. 2002 May;15(9):1557-62. doi: 10.1046/j.1460-9568.2002.01994.x.
Neuronal networks underlying and related to horizontal eye movements were visualized by retrograde transneuronal tracing with rabies virus from the left medial rectus muscle in guinea pigs. Time-sequenced labelling revealed distinct circuitries involved in particular oculomotor functions, i.e. vestibulo-ocular reflex and saccade generation (brainstem circuitry), adaptive plasticity (cerebellar modules) and possibly motivation and navigation (limbic, hippocampal and cortical structures). Our results provide a first comprehensive road map of the oculomotor system that is unsurpassed by any previous tracing study. We report a number of unexpected findings that illustrate a much vaster and more complicated network for the control of the relatively simple horizontal eye movements than had been envisioned previously.
通过对豚鼠左内直肌进行狂犬病病毒逆行跨神经元追踪，可视化了与水平眼动相关及潜在的神经网络。时间序列标记揭示了参与特定眼球运动功能的不同回路，即前庭眼反射和扫视产生（脑干回路）、适应性可塑性（小脑模块）以及可能的动机和导航（边缘系统、海马体和皮质结构）。我们的结果提供了眼球运动系统的首张全面路线图，这是以往任何追踪研究都无法比拟的。我们报告了一些意外发现，这些发现表明，控制相对简单的水平眼动的网络比之前预想的要庞大和复杂得多。
