Tommaselli G A, Pellicano M, Guida M, Palomba S, Savarese F, Nola B, Ferrara C, Lapadula C, Nappi C
Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Università degli Studi di Napoli, Federico II, Napoli, Italy.
Minerva Ginecol. 2002 Apr;54(2):145-50.
Maternal endocrine disorders can have detrimental effects on the fetus and the pregnancy can affect the course of a pre-exisiting endocrinopathy or induce the onset of one of these disorders. Therapies for endocrine disorders are not always safe to administer during pregnancy. Before administering any therapy to the mother, the effects on the fetus, the degree of placental trespassing as well as the potential damaging effects must be assessed. An accurate evaluation of the risks/benefits of any drug to be used on the mother is needed, assessing above all a potential theratogenic effect. In this review, the incidence of the main endocrine disorders, their evolution during pregnancy, their effects on mothers and fetuses and new acquisition on the treatment during pregnancy are discussed.
母体内分泌紊乱会对胎儿产生不利影响，而妊娠也可能影响既往存在的内分泌疾病的病程或引发这些疾病之一。内分泌疾病的治疗在孕期使用时并不总是安全的。在给母亲使用任何治疗方法之前，必须评估其对胎儿的影响、胎盘侵入程度以及潜在的损害作用。需要准确评估任何用于母亲的药物的风险/益处，尤其要评估潜在的致畸作用。在本综述中，将讨论主要内分泌疾病的发病率、孕期演变、对母亲和胎儿的影响以及孕期治疗的新进展。
