Antolak John A, Bieda Michael R, Hogstrom Kenneth R
Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston 77030-4009, USA.
Med Phys. 2002 May;29(5):771-86. doi: 10.1118/1.1469626.
The purpose of this study was to investigate the feasibility of using Monte Carlo methods to assist in the commissioning of electron beams for a medical linear accelerator. The EGS4/BEAM code system was used to model an installed linear accelerator at this institution. Following an initial tuning of the input parameters, dosimetry data normally measured during the machine commissioning was calculated using the Monte Carlo code. All commissioning data was calculated for 6- and 12-MeV electron beams, and a subset of the commissioning data was calculated for the 20-MeV electron beams. On central axis, calculated percentage depth dose, cross-beam profiles, cone-insert ratios, and air-gap factors were generally within 2% of Dmax or 1 mm of the measured commissioning data; however, calculated open-cone ratios were not within 2%, in most cases. Calculated off-axis dose profiles for small fields were generally within the 2% (1-mm) criteria; however, calculated dose profiles for larger (open cone) fields frequently failed the 2% (1-mm) criteria. The remaining discrepancies between Monte Carlo calculations and measurement could be due to flaws in the Monte Carlo code, inaccuracies in the simulation geometry, the approximation of the initial source configuration, or a combination of the above. Although agreement between Monte Carlo calculated and measured doses was impressive and similar to previously published comparisons, our results did not prove our hypothesis that Monte Carlo calculations can generate electron commissioning data that is accurate within 2% of Dmax or 0.1 cm over the entire range of clinical treatment parameters. Although we believe that this hypothesis can be proved, it remains a challenge for the medical physics community. We intend to pursue this further by developing systematic methods for isolating causes of these differences.
本研究的目的是探讨使用蒙特卡罗方法辅助医用直线加速器电子束调试的可行性。采用EGS4/BEAM代码系统对本机构安装的直线加速器进行建模。在对输入参数进行初步调整后,使用蒙特卡罗代码计算机器调试期间通常测量的剂量学数据。所有调试数据均针对6 MeV和12 MeV电子束进行计算,部分调试数据针对20 MeV电子束进行计算。在中心轴上,计算得到的百分深度剂量、束流剖面、锥插比和气隙因子通常在Dmax的2%以内或与测量的调试数据相差1 mm以内;然而,在大多数情况下,计算得到的开放锥比不在2%以内。小射野的离轴剂量剖面计算结果通常符合2%(1 mm)的标准;然而,大(开放锥)射野的剂量剖面计算结果经常不符合2%(1 mm)的标准。蒙特卡罗计算与测量之间的其余差异可能是由于蒙特卡罗代码的缺陷、模拟几何形状的不准确、初始源配置的近似,或上述因素的综合影响。尽管蒙特卡罗计算剂量与测量剂量之间的一致性令人印象深刻,且与先前发表的比较结果相似,但我们的结果并未证明我们的假设,即蒙特卡罗计算能够生成在整个临床治疗参数范围内Dmax的2%或0.1 cm以内准确的电子束调试数据。尽管我们相信这个假设可以得到证明,但这对医学物理界来说仍然是一个挑战。我们打算通过开发系统方法来隔离这些差异的原因,进一步探讨这个问题。