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临床成形电子射野输出因子的蒙特卡罗计算

Monte Carlo calculations of output factors for clinically shaped electron fields.

作者信息

Turian Julius V, Smith Brett D, Bernard Damian A, Griem Katherine L, Chu James C

机构信息

Department of Radiation Oncology, University of Illinois Medical Center, OCC C-400, 1801 W. Taylor Street, Chicago, Illinois 60612, USA.

出版信息

J Appl Clin Med Phys. 2004 Spring;5(2):42-63. doi: 10.1120/jacmp.v5i2.1976. Epub 2004 Apr 1.

Abstract

We report on the use of the EGS4/BEAM Monte Carlo technique to predict the output factors for clinically relevant, irregularly shaped inserts as they intercept a linear accelerator's electron beams. The output factor for a particular combination--energy, cone, insert, and source-to-surface distance (SSD)--is defined in accordance with AAPM TG-25 as the product of cone correction factor and insert correction factor, evaluated at the depth of maximum dose. Since cone correction factors are easily obtained, we focus our investigation on the insert correction factors (ICFs). An analysis of the inserts used in routine clinical practice resulted in the identification of a set of seven "idealized" shapes characterized by specific parameters. The ICFs for these shapes were calculated using a Monte Carlo method (EGS4/BEAM) and measured for a subset of them using an ion chamber and well-established measurement methods. Analytical models were developed to predict the Monte Carlo-calculated ICF values for various electron energies, cone sizes, shapes, and SSDs. The goodness-of-fit between predicted and Monte Carlo-calculated ICF values was tested using the Kolmogorov-Smirnoff statistical test. Results show that Monte Carlo-calculated ICFs match the measured values within 2.0% for most of the shapes considered, except for few highly elongated fields, where deviations up to 4.0% were recorded. Predicted values based on analytical modeling agree with measured ICF values within 2% to 3% for all configurations. We conclude that the predicted ICF values based on modeling of Monte Carlo-calculated values could be introduced in clinical use.

摘要

我们报告了使用EGS4/BEAM蒙特卡罗技术来预测临床相关的不规则形状插入物在拦截直线加速器电子束时的输出因子。根据美国医学物理学家协会(AAPM)TG - 25,特定组合(能量、准直器、插入物和源皮距(SSD))的输出因子定义为在最大剂量深度处评估的准直器校正因子与插入物校正因子的乘积。由于准直器校正因子很容易获得,我们将研究重点放在插入物校正因子(ICF)上。对常规临床实践中使用的插入物进行分析后,确定了一组由特定参数表征的七个“理想化”形状。使用蒙特卡罗方法(EGS4/BEAM)计算这些形状的ICF,并使用电离室和成熟的测量方法对其中一部分进行测量。开发了分析模型来预测各种电子能量、准直器尺寸、形状和SSD下蒙特卡罗计算的ICF值。使用柯尔莫哥洛夫 - 斯米尔诺夫统计检验来测试预测的ICF值与蒙特卡罗计算的ICF值之间的拟合优度。结果表明,对于大多数考虑的形状,蒙特卡罗计算的ICF与测量值的匹配度在2.0%以内,但对于少数高度拉长的射野,记录到的偏差高达4.0%。对于所有配置,基于分析模型的预测值与测量的ICF值在2%至3%以内相符。我们得出结论,基于蒙特卡罗计算值建模预测的ICF值可引入临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3969/5723462/07c36840526d/ACM2-5-42-g003.jpg

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