Kurosaki Tomohiro
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Japan.
Nat Rev Immunol. 2002 May;2(5):354-63. doi: 10.1038/nri801.
An important role has emerged for adaptor molecules in linking cell-surface receptors, such as the B-cell antigen receptor, with effector enzymes. Adaptor proteins direct the appropriate subcellular localization of effectors and regulate their activity by inducing conformational changes, both of which, in turn, contribute to the spatio-temporal precision of B-cell signal-transduction events. In addition, adaptor molecules participate in establishing negative- or positive-feedback regulatory loops in signalling networks, thereby fine-tuning the B-cell response.
衔接分子在连接细胞表面受体（如B细胞抗原受体）与效应酶方面发挥了重要作用。衔接蛋白指导效应器在亚细胞中的适当定位，并通过诱导构象变化来调节其活性，这两者反过来又有助于B细胞信号转导事件的时空精确性。此外，衔接分子参与在信号网络中建立负反馈或正反馈调节回路，从而微调B细胞反应。
