Mukamal Kenneth J, Maclure Malcolm, Muller James E, Sherwood Jane B, Mittleman Murray A
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Circulation. 2002 May 28;105(21):2476-81. doi: 10.1161/01.cir.0000017201.88994.f7.
Some studies have suggested that tea consumption may be associated with lower mortality among individuals with cardiovascular disease, but the effects of tea consumption on mortality after acute myocardial infarction are unknown.
As part of the Determinants of Myocardial Infarction Onset Study, we performed a prospective cohort study of 1900 patients hospitalized with a confirmed acute myocardial infarction between 1989 and 1994, with a median follow-up of 3.8 years. Trained interviewers assessed self-reported usual weekly caffeinated tea consumption during the year before infarction with a standardized questionnaire. We compared long-term mortality according to tea consumption using Cox proportional hazards regression. Of the 1900 patients, 1019 consumed no tea (nondrinkers), 615 consumed <14 cups per week (moderate tea drinkers), and 266 consumed 14 or more cups per week (heavy tea drinkers). Compared with nondrinkers, age- and sex-adjusted mortality was lower among moderate tea drinkers (hazard ratio, 0.69; 95% CI, 0.53 to 0.89) and heavy tea drinkers (hazard ratio, 0.61; 95% CI, 0.42 to 0.86). Additional adjustment for clinical and sociodemographic characteristics did not appreciably alter this association (hazard ratio, 0.72; 95% CI, 0.55 to 0.94 for moderate tea drinkers; hazard ratio, 0.56; 95% CI, 0.37 to 0.84 for heavy tea drinkers). The association of tea and mortality was similar for total and cardiovascular mortality.
Self-reported tea consumption in the year before acute myocardial infarction is associated with lower mortality after infarction.
一些研究表明，饮茶可能与心血管疾病患者较低的死亡率相关，但饮茶对急性心肌梗死后死亡率的影响尚不清楚。
作为心肌梗死发病决定因素研究的一部分，我们对1989年至1994年间确诊为急性心肌梗死住院的1900例患者进行了一项前瞻性队列研究，中位随访时间为3.8年。经过培训的访谈员使用标准化问卷评估了梗死前一年自我报告的每周通常含咖啡因茶的饮用量。我们使用Cox比例风险回归比较了根据饮茶情况的长期死亡率。在这1900例患者中，1019例不饮茶（不饮茶者），615例每周饮用少于14杯（适度饮茶者），266例每周饮用14杯或更多杯（重度饮茶者）。与不饮茶者相比，适度饮茶者（风险比，0.69；95%可信区间，0.53至0.89）和重度饮茶者（风险比，0.61；95%可信区间，0.42至0.86）经年龄和性别调整后的死亡率较低。对临床和社会人口学特征进行额外调整并没有明显改变这种关联（适度饮茶者风险比，0.72；95%可信区间，0.55至0.94；重度饮茶者风险比，0.56；95%可信区间，0.37至0.84）。茶与死亡率的关联在总死亡率和心血管死亡率方面相似。
急性心肌梗死前一年自我报告的饮茶情况与梗死后较低的死亡率相关。
