Bateni Motahare, Zarepur Ehsan, Haghighatdoost Fahimeh, Mohammadifard Noushin, Dianatkhah Minoo, Khosravi Farsani Alireza, Azdaki Nahid, Salehi Nahid, Lotfizadeh Masoud, Ghaffari Samad, Salari Arsalan, Cheraghi Mostafa, Assareh Ahmadreza, Arefianjazi Mehrnoosh, Sarrafzadegan Nizal
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran.
Interventional Cardiology Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran.
Food Sci Nutr. 2025 Sep 26;13(10):e70943. doi: 10.1002/fsn3.70943. eCollection 2025 Oct.
There is no evidence to prove the relationship between Dietary Phytochemical Index (DPI) and the incidence of premature coronary artery disease (PCAD) among the Iranian population. Therefore, this research investigates the association between the DPI score and the odds of PCAD within a nationally representative Iranian population. This case-control study was performed on 3161 ( = 2006 case and = 1155 control) Iranian population < 70 y in women and < 60 y in men. Subjects showing normal results on coronary angiography comprised the control group, and those with stenotic lesions exceeding 75% in at least one coronary artery or over 50% in the left main coronary artery were identified as the case group. Information on dietary intake was collected using a validated 110-item food frequency questionnaire. Using the McCarthy equation, the DPI was calculated. A binary logistic regression model was used to evaluate the association between DPI and PCAD. The mean age of the study population was 53.7 (SD = 7.6) years, and 45.1% of them were female. In the unadjusted model, individuals in the highest quartile of DPI exhibited a significantly reduced likelihood of developing PCAD compared to those in the lowest quartile (OR = 0.25, 95% CI: 0.20-0.31, trend < 0.001). Adjustment for potential confounders further reinforced the relationship, indicating that participants in the top DPI quartile had 89% reduced odds of PCAD relative to those in the first quartile (95% CI: 0.08-0.17, trend < 0.001). Our findings revealed a significant negative association between the DPI and the odds of PCAD. However, more research is necessary to determine this association.
没有证据证明伊朗人群中饮食植物化学指数（DPI）与早发性冠状动脉疾病（PCAD）发病率之间的关系。因此，本研究调查了伊朗全国代表性人群中DPI得分与PCAD发生几率之间的关联。这项病例对照研究针对年龄小于70岁的女性和小于60岁的男性的3161名伊朗人群进行（病例组=2006例，对照组=1155例）。冠状动脉造影结果正常的受试者组成对照组，至少一条冠状动脉狭窄病变超过75%或左主干冠状动脉狭窄超过50%的受试者被确定为病例组。使用经过验证的110项食物频率问卷收集饮食摄入信息。使用麦卡锡方程计算DPI。采用二元逻辑回归模型评估DPI与PCAD之间的关联。研究人群的平均年龄为53.7岁（标准差=7.6），其中45.1%为女性。在未调整模型中，与最低四分位数的个体相比，DPI最高四分位数的个体发生PCAD的可能性显著降低（比值比=0.25，95%置信区间：0.20-0.31，趋势<0.001）。对潜在混杂因素进行调整进一步强化了这种关系，表明DPI最高四分位数的参与者发生PCAD的几率比第一四分位数的参与者降低了89%（95%置信区间：0.08-0.17，趋势<0.001）。我们的研究结果揭示了DPI与PCAD发生几率之间存在显著的负相关。然而，需要更多的研究来确定这种关联。
