Kreiman Gabriel, Fried Itzhak, Koch Christof
Computation and Neural Systems Program, California Institute of Technology 139-74, Pasadena, CA 91125, USA.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8378-83. doi: 10.1073/pnas.072194099. Epub 2002 May 28.
Visual information from the environment is transformed into perceptual sensations through several stages of neuronal processing. Flash suppression constitutes a striking example in which the same retinal input can give rise to two different conscious visual percepts. We directly recorded the responses of individual neurons during flash suppression in the human amygdala, entorhinal cortex, hippocampus, and parahippocampal gyrus, allowing us to explore the neuronal responses in untrained subjects at a high spatial and temporal resolution in the medial temporal lobe. Subjects were patients with pharmacologically intractable epilepsy implanted with depth electrodes to localize the seizure onset focus. We observed that the activity of two thirds of all visually selective neurons followed the perceptual alternations rather than the retinal input. None of the selective neurons responded to a perceptually suppressed stimulus. Therefore, the activity of most individual neurons in the medial temporal lobe of naive human subjects directly correlates with the phenomenal visual experience.
来自环境的视觉信息通过神经元处理的几个阶段转化为感知觉。闪光抑制就是一个显著的例子，在这个例子中，相同的视网膜输入可以产生两种不同的有意识视觉感知。我们直接记录了人类杏仁核、内嗅皮质、海马体和海马旁回在闪光抑制期间单个神经元的反应，这使我们能够在内侧颞叶以高空间和时间分辨率探索未经训练的受试者的神经元反应。受试者是植入深度电极以定位癫痫发作起始灶的药物难治性癫痫患者。我们观察到，所有视觉选择性神经元中有三分之二的活动跟随感知交替，而不是视网膜输入。没有一个选择性神经元对感知上被抑制的刺激做出反应。因此，未接触过相关实验的人类受试者内侧颞叶中大多数单个神经元的活动与视觉体验直接相关。
