一种用于芳基烷基酮立体选择性霍纳-沃兹沃思-埃蒙斯反应的简便方法。
A facile method for the stereoselective Horner-Wadsworth-Emmons reaction of aryl alkyl ketones.
作者信息
Sano Shigeki, Yokoyama Kenji, Shiro Motoo, Nagao Yoshimitsu
机构信息
Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2002 May;50(5):706-9. doi: 10.1248/cpb.50.706.
PMID:12036038
Abstract
Excellent Z or E selectivity was observed in the Horner-Wadsworth-Emmons (HWE) reactions of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate or ethyl 2-fluoro-2-diethylphosphonoacetate with aryl alkyl ketones bearing substituents on an aromatic moiety employing Sn(OSO2CF3)2 in the presence of N-ethylpiperidine.
摘要
在N-乙基哌啶存在下，使用二(三氟甲磺酸)锡，甲基双(2,2,2-三氟乙基)膦酰基乙酸酯或2-氟-2-二乙基膦酰基乙酸乙酯与芳环上带有取代基的芳基烷基酮进行霍纳-沃兹沃思-埃蒙斯（HWE）反应时，观察到了出色的Z式或E式选择性。
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