一种基于 MW 辅助的 Horner-Wadsworth-Emmons 反应的高效合成（Z）-3,3-三取代-α，β-不饱和酯的方法。
An efficient procedure based on a MW-assisted Horner-Wadsworth-Emmons reaction for the synthesis of (Z)-3,3-trisubstituted-alpha,beta-unsaturated esters.
机构信息
Dipartimento di Chimica Farmaceutica, viale Taramelli 12, Pavia 27100, Italy.
出版信息
Molecules. 2010 Aug 27;15(9):5928-42. doi: 10.3390/molecules15095928.
Abstract
A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-alpha,beta-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.
摘要
已开发出一种微波辅助的 HWE 烯丙基化反应过程，可方便地对芳基-烷基酮进行反应，从而快速得到（Z）-3,3-三取代-α,β-不饱和甲基酯，这是合成生物活性化合物的关键构建块。
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