Miyata Kazunori, Tsuji Hideki, Tanabe Tatsuro, Mimura Yoshiko, Amano Shiro, Oshika Tetsuro
Meiwakai Medical Foundation, Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan
Am J Ophthalmol. 2002 Jun;133(6):750-2. doi: 10.1016/s0002-9394(02)01437-x.
To evaluate the efficacy and safety of intracameral air injection in treating acute hydrops in keratoconus.
Retrospective, nonrandomized, comparative trial.
Thirty eyes (30 patients) with acute hydrops secondary to keratoconus.
Nine eyes (nine patients) with acute hydrops in keratoconus were treated with intracameral injection of 0.1 ml filtered air. Additional 0.1 ml filtered air was injected if corneal edema persisted when air disappeared from the anterior chamber. Twenty-one eyes (21 patients) with acute hydrops that received no therapy or conventional therapy not likely to shorten the duration of hydrops served as controls.
The period of persistence of corneal edema, the interval between the onset of acute hydrops, and the time when the eye could begin to wear a hard-contact lens, and best spectacle-corrected and hard-contact lens-corrected visual acuity after corneal edema subsided were used as criteria to evaluate any differences between the two groups.
The average period of persistence of corneal edema was 20.1 +/- 9.0 days (+/- SD) in the intracameral air injection group and 64.7 +/- 34.6 days in the control (P =.0008). The average interval between the onset of acute hydrops and the time when the eye could begin to wear a hard-contact lens, was 33.4 +/- 5.6 days in the air injection group and 128.9 +/- 85.8 days in the control group (P =.0058). The best-corrected visual acuity after corneal edema subsided was similar between the two groups. Intracameral air injection induced no complications.
The results suggest that the intracameral air injection is a safe and useful therapy to shorten the period of corneal edema in acute hydrops secondary to keratoconus.
评估前房内注射空气治疗圆锥角膜急性水肿的疗效和安全性。
回顾性、非随机、对照试验。
30例圆锥角膜继发急性水肿患者的30只眼。
9例圆锥角膜急性水肿患者的9只眼接受前房内注射0.1 ml过滤空气治疗。若前房内空气消失后角膜水肿仍持续，则额外注射0.1 ml过滤空气。21例圆锥角膜急性水肿患者的21只眼未接受治疗或接受了不太可能缩短水肿持续时间的传统治疗，作为对照组。
以角膜水肿持续时间、急性水肿发作至患眼可开始佩戴硬性接触镜的间隔时间，以及角膜水肿消退后的最佳矫正视力和硬性接触镜矫正视力作为评估两组差异的标准。
前房内注射空气组角膜水肿平均持续时间为20.1±9.0天（±标准差），对照组为64.7±34.6天（P = 0.0008）。前房内注射空气组急性水肿发作至患眼可开始佩戴硬性接触镜的平均间隔时间为33.4±5.6天，对照组为128.9±85.8天（P = 0.0058）。两组角膜水肿消退后的最佳矫正视力相似。前房内注射空气未引起并发症。
结果表明，前房内注射空气是一种安全有效的治疗方法，可缩短圆锥角膜继发急性水肿的角膜水肿持续时间。
