Panda Anita, Aggarwal Anand, Madhavi Pragati, Wagh Vijay B, Dada Tanuj, Kumar Abhiyan, Mohan Shalini
Cornea, OSD, and Refractive Surgery Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Cornea. 2007 Oct;26(9):1067-9. doi: 10.1097/ICO.0b013e31805444ba.
To report the use of sulfur hexafluoride (SF6) gas in the management of corneal edema caused by acute corneal hydrops secondary to keratoconus.
Nine eyes with acute hydrops secondary to keratoconus managed by SF6 gas injected into the anterior chamber (group 1) were compared to another 9 eyes that were managed conservatively with conventional medical therapy (group 2).
Of 9 eyes in group 1, 3 had 1 injection, 4 had 2 injections, and the remaining 2 had 3 injections into the anterior chamber. All the eyes in group 1 showed an early resolution of corneal edema at 4 weeks. The same was achieved in group 2 at 12 weeks. The central corneal thickness (CCT) in group 1 and group 2 was >1.0 mm at presentation. The CCT at 3 and 12 weeks in group 1 was 0.99 and 0.65 mm, respectively, whereas CCT in group 2 at 3 weeks was >1.0 mm and at 12 weeks was 0.991 mm (P = 0.001). The mean best spectacle-corrected visual acuity (BSCVA) at 12 weeks in group 1 and group 2 was 0.39 and 0.24, respectively (P = 0.016). The results were significant in favor of group 1 over group 2 both in CCT and BSCVA.
Early intervention with intracameral SF6 injection is a safe and effective therapy for early reduction of corneal edema in eyes with keratoconus and acute hydrops.
报告六氟化硫（SF6）气体在治疗圆锥角膜继发急性角膜水肿中的应用。
将9只因圆锥角膜继发急性角膜水肿而向前房内注射SF6气体进行治疗的眼睛（第1组）与另外9只采用传统药物保守治疗的眼睛（第2组）进行比较。
第1组的9只眼中，3只眼进行了1次注射，4只眼进行了2次注射，其余2只眼进行了3次前房注射。第1组所有眼睛在4周时角膜水肿均早期消退。第2组在12周时达到同样效果。第1组和第2组就诊时中央角膜厚度（CCT）均>1.0 mm。第1组在3周和12周时的CCT分别为0.99 mm和0.65 mm，而第2组在3周时CCT>1.0 mm，在12周时为0.991 mm（P = 0.001）。第1组和第2组在12周时的平均最佳矫正视力（BSCVA）分别为0.39和0.24（P = 0.016）。在CCT和BSCVA方面，第1组的结果均显著优于第2组。
前房内注射SF6进行早期干预是治疗圆锥角膜合并急性角膜水肿、早期减轻角膜水肿的一种安全有效的方法。
