Martin Karen H, Slack Jill K, Boerner Scott A, Martin Clifford C, Parsons J Thomas
Department of Microbiology, University of Virginia Health System, Box 800734, Charlottesville, VA 22908-0734, USA.
Science. 2002 May 31;296(5573):1652-3. doi: 10.1126/science.296.5573.1652.
Integrins are transmembrane proteins that serve as primary sensors of the extracellular matrix (ECM) environment. In response to interactions with the ECM, integrins initiate signaling pathways that regulate cell migration, growth, and survival. Advances in imaging have contributed to the understanding of the dynamic nature of these cell-ECM interactions and the complexes that form at these sites and have provided insights into their regulation and signal organizing functions.
整合素是跨膜蛋白，作为细胞外基质（ECM）环境的主要传感器。响应与ECM的相互作用，整合素启动调节细胞迁移、生长和存活的信号通路。成像技术的进步有助于理解这些细胞与ECM相互作用的动态性质以及在这些位点形成的复合物，并为其调节和信号组织功能提供了见解。
