Huveneers Stephan, Danen Erik H J
Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands.
J Cell Sci. 2009 Apr 15;122(Pt 8):1059-69. doi: 10.1242/jcs.039446.
Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth factors. Over the past years, it has become clear that there is extensive crosstalk between integrins, Src-family kinases and Rho-family GTPases at the heart of such adhesion signaling. In this Commentary, we discuss recent advances in our understanding of the dynamic regulation of the molecular connections between these three protein families. We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction.
细胞与细胞外基质之间的相互作用协调着控制细胞行为各个方面的信号通路。整合素感知细胞外基质的物理特性并相应地组织细胞骨架。反过来，这又调节了由各种其他跨膜受体触发的信号通路，并增强了细胞对生长因子的反应。在过去几年中，很明显，在这种黏附信号的核心，整合素、Src家族激酶和Rho家族GTP酶之间存在广泛的相互作用。在这篇评论中，我们讨论了我们对这三个蛋白质家族之间分子连接的动态调节的最新理解进展。我们还讨论了这个信号网络如何调节一系列对正常组织功能和疾病很重要的细胞过程，包括细胞黏附、铺展、迁移和机械转导。
