Espinola L G, Beaucaire J, Gottschalk A, Caride V J
J Nucl Med. 1979 May;20(5):434-40.
We describe the organ distribution of positively and negatively charged multilamellar lipid vesicles (MLV) labeled with Tc-99m DTPA or In-111 oxine in mice. The organ distribution of MLV (In-111 oxine) is fairly constant throughout 72 hr, indicating that the radiotracer remains associated with cellular structures at the site of MLV uptake. In animals injected with MLV (Tc-99m DTPA), on the other hand, there is continuous leakage of radioactivity from the involved organs. This can be explained by the release of the radiotracer following MLV destruction in the organs. MLV (IN-111 oxine) may be used to study MLV uptake by different organs, whereas MLV (Tc-99m DTPA) may be a good indicator of the destruction rate of lipid vesicles. Various conditions bearing on liposome kinetics merit further study in order to assess the potentialities of these vectors as diagnostic or therapeutic agents.
我们描述了用锝-99m二乙三胺五乙酸（Tc-99m DTPA）或铟-111奥克辛（In-111 oxine）标记的带正电和带负电的多层脂质囊泡（MLV）在小鼠体内的器官分布。MLV（铟-111奥克辛）在72小时内的器官分布相当稳定，这表明放射性示踪剂在MLV摄取部位仍与细胞结构相关。另一方面，在注射了MLV（Tc-99m DTPA）的动物中，相关器官存在放射性的持续泄漏。这可以通过器官中MLV破坏后放射性示踪剂的释放来解释。MLV（铟-111奥克辛）可用于研究不同器官对MLV的摄取，而MLV（Tc-99m DTPA）可能是脂质囊泡破坏率的良好指标。为了评估这些载体作为诊断或治疗剂的潜力，与脂质体动力学相关的各种条件值得进一步研究。
