McAfee J G, Gagne G, Atkins H L, Kirchner P T, Reba R C, Blaufox M D, Smith E M
J Nucl Med. 1979 Dec;20(12):1273-8.
For the purpose of radiation dose estimates, organ assays and excretion measurements of the Tc-99m and In-111 complexes with DTPA were conducted in dogs at various time intervals up to 24 hr, and the results compared with available human data. The peak concentration of the Tc-99m complex, at 3 min after injection, was 5% of the administered dose for one kidney, 3.5% for the liver, and 3.5% for the small bowel. No organ system except the urinary tract reached a concentration higher than that in blood for several hours after the injection. The biliary excretion of these agents was extremely low, and their elimination in the feces was negligible. In man, it appears that the residual 4-5% of an administered dose not eliminated in the urine by 24 hr is widely distributed in various tissues. The distribution of the In-111 complex is similar but not identical to that of the Tc-99m complex.
为了进行辐射剂量估计，在狗身上于长达24小时的不同时间间隔进行了锝-99m和铟-111与二乙三胺五乙酸（DTPA）复合物的器官分析和排泄测量，并将结果与现有的人体数据进行了比较。注射后3分钟时，锝-99m复合物的峰值浓度，一个肾脏为给药剂量的5%，肝脏为3.5%，小肠为3.5%。注射后数小时内，除泌尿系统外，没有任何器官系统的浓度高于血液中的浓度。这些药物的胆汁排泄极低，粪便中的消除量可忽略不计。在人体中，似乎到24小时时未在尿液中消除的给药剂量的4-5%残留在体内，并广泛分布于各种组织中。铟-111复合物的分布与锝-99m复合物相似但不完全相同。
