Howard Louise Michele, Kumar Channi, Leese Morven, Thornicroft Graham
Health Services Research Department, Institute of Psychiatry, King's College, London, UK.
Am J Psychiatry. 2002 Jun;159(6):991-7. doi: 10.1176/appi.ajp.159.6.991.
This study determined the general fertility rate and age-specific fertility rates for women with psychotic disorders.
This historical matched-cohort study of patient records from a primary care database (the General Practice Research Database) was carried out for women of childbearing age (15-44 years) with psychotic disorders.
The women with psychotic disorders (N=7,936) had a lower overall general fertility rate than the normal comparison subjects (N=23,023), although fertility was only significantly lower in the women aged 25 and above. This lower fertility rate was less marked in women with affective psychoses. There was no evidence that treatment with neuroleptics influenced the fertility rate in women with non-affective psychoses.
This study found markedly lower fertility rates in women with psychotic disorders than in matched normal comparison subjects, particularly in women with non-affective disorders. Knowledge of fertility rates in women with psychotic disorders is fundamental for clinicians and researchers, since it has implications for family planning services, prevention of obstetric complications, child-care support, and hypotheses about the etiology of these disorders.
本研究确定了患有精神障碍女性的总生育率和年龄别生育率。
对来自初级保健数据库（全科医疗研究数据库）的育龄期（15 - 44岁）患有精神障碍女性的患者记录进行了这项历史性匹配队列研究。
患有精神障碍的女性（N = 7936）的总体总生育率低于正常对照对象（N = 23023），不过仅25岁及以上女性的生育率显著较低。患有情感性精神病的女性中这种较低的生育率不太明显。没有证据表明使用抗精神病药物治疗会影响非情感性精神病女性的生育率。
本研究发现患有精神障碍的女性生育率明显低于匹配的正常对照对象，尤其是患有非情感性障碍的女性。了解患有精神障碍女性的生育率对于临床医生和研究人员至关重要，因为这对计划生育服务、预防产科并发症、儿童保育支持以及这些疾病的病因假说都有影响。
