Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA.
Psychiatry Investig. 2011 Sep;8(3):214-20. doi: 10.4306/pi.2011.8.3.214. Epub 2011 Aug 2.
To evaluate reproduction among patients with bipolar I disorder (BP1) or schizophrenia (SZ) in Egypt.
BP1 patients (n=113) were compared with community based, demographically balanced controls (n=124) and SZ patients (n=79, DSM-IV). All participants were evaluated using structured interviews and corroborative data were obtained from relatives. Standard indices of procreation were included in multivariate analyses that incorporated key demographic variables.
Control individuals were significantly more likely to have children than BP1 or SZ patients (controls 46.8%, BP1 15.9%, SZ 17.7%), but the BP1-SZ differences were non-significant. The average number of children for BP1 patients (0.37±0.9) and SZ patients (0.38±0.9) was significantly lower than for controls (1.04±1.48) (BP1 vs controls, p<0.001; SZ vs controls, p<0.001). The frequency of marriages among BP1 patients was nominally higher than the SZ group, but was significantly lower than controls (BP1: 31.9% SZ: 27.8% control: 57.3%). Even among married individuals, BP1 (but not SZ) patients were childless more often than controls (p=0.001). The marital fertility, i.e., the average number of children among patients with conjugal relationships for controls (1.8±1.57) was significantly higher than BP1 patients (1.14±1.31, p=0.02), but not significantly different from SZ patients (1.36±1.32, p=0.2).
Selected reproductive measures are significantly and substantially reduced among Egyptian BP1 patients. The reproductive indices are similar among BP1 and SZ patients, suggesting a role for general illness related variables. Regardless of the cause/s, the impairment constitutes important, under-investigated disability.
评估埃及的双相 I 障碍（BP1）或精神分裂症（SZ）患者的生育情况。
将 BP1 患者（n=113）与基于社区、人口统计学平衡的对照组（n=124）和 SZ 患者（n=79，DSM-IV）进行比较。所有参与者均接受了结构化访谈，并从亲属那里获得了佐证数据。标准生育指标纳入了包含关键人口统计学变量的多变量分析。
对照组个体拥有子女的可能性显著高于 BP1 或 SZ 患者（对照组 46.8%，BP1 15.9%，SZ 17.7%），但 BP1 与 SZ 之间的差异无统计学意义。BP1 患者（0.37±0.9）和 SZ 患者（0.38±0.9）的平均子女数明显低于对照组（1.04±1.48）（BP1 与对照组相比，p<0.001；SZ 与对照组相比，p<0.001）。BP1 患者的婚姻频率名义上高于 SZ 组，但显著低于对照组（BP1：31.9%，SZ：27.8%，对照组：57.3%）。即使在已婚个体中，BP1（但非 SZ）患者的不育率也高于对照组（p=0.001）。婚姻生育率，即对照组有婚姻关系的患者的平均子女数（1.8±1.57）明显高于 BP1 患者（1.14±1.31，p=0.02），但与 SZ 患者无显著差异（1.36±1.32，p=0.2）。
埃及 BP1 患者的一些特定生育指标明显且显著降低。BP1 和 SZ 患者的生育指数相似，提示与一般疾病相关的变量起作用。无论原因是什么，这种损害构成了重要但研究不足的残疾。
