左旋四咪唑。增强人类淋巴细胞对抗原的反应。
L-tetramisole. Enhancement of human lymphocyte response to antigen.
作者信息
Pabst H F, Crawford J
出版信息
Clin Exp Immunol. 1975 Sep;21(3):468-73.
Abstract
The anthelminthic drug L-Tetramisole enhanced in vitro lymphocyte transformation of normal young adults in the presence of PPD, Candida or measles antigen. This enhancement occurred regardless of evident pre-existing immunity to the antigen used. The increase in stimulation obtained by the drug and antigen combined, beyond that by antigen alone, varied between 1-25 and 5-99 for all three antigens in fourteen cell donors. Lymphocyte transformation was induced in seven individuals by the drug alone and suppressed in two. In levamisole dose--response tests, the optimum dose for this in vitro effect in six donors was similar for the three antigens.
摘要
驱虫药左旋四咪唑在有结核菌素纯蛋白衍生物（PPD）、白色念珠菌或麻疹抗原存在的情况下，可增强正常年轻人的体外淋巴细胞转化。无论对所用抗原是否已有明显的预先存在的免疫力，这种增强作用都会发生。在14名细胞供体中，药物与抗原联合使用所获得的刺激增加量（超过单独使用抗原时），对于所有三种抗原而言，在1 - 25至5 - 99之间变化。单独使用药物可诱导7个人的淋巴细胞转化，而在2个人中则受到抑制。在左旋咪唑剂量 - 反应试验中，6名供体中产生这种体外效应的最佳剂量对于三种抗原是相似的。
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本文引用的文献
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