Seĭbil' V B
Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2002 Mar-Apr(2):107-13.
In 1988 the World Health Assembly resolved to eradicate poliomyelitis globally by the year 2000. The work continues. The problem arose how to quit the system of mass immunization with oral poliovirus vaccine (OPV) without trouble and to achieve the disappearance of polioviruses worldwide. After the cessation of the OPV use a certain number of vaccine viruses may remain that will circulate among the ever growing number of nonimmune population. Live enterovirus vaccines prepared from nonpathogenic serotypes of ECHO virus are proposed for application to stop the circulation of vaccine poliovirus. These vaccines will make it possible to eliminate the remaining vaccine viruses from circulation and to complete the process of worldwide poliomyelitis eradication.
1988年，世界卫生大会决定到2000年在全球根除脊髓灰质炎。这项工作仍在继续。问题在于如何顺利停用口服脊髓灰质炎病毒疫苗（OPV）大规模免疫接种系统，并实现全球脊髓灰质炎病毒的消失。停用OPV后，可能会有一定数量的疫苗病毒留存，它们会在不断增加的未免疫人群中传播。有人提议使用由埃可病毒非致病性血清型制备的肠道病毒活疫苗，以阻止疫苗脊髓灰质炎病毒的传播。这些疫苗将有可能消除仍在传播的疫苗病毒，从而完成全球根除脊髓灰质炎的进程。
